"Addressing joint loading during locomotion as the means of developing OA prevention and rehabilitation approaches deserves equal attention in relation to other drug and biologic therapies. Identifying conditions creating joint overuse and aberrant joint rotation at impact, and utilizing strategies similar to NMT training in human athletes tailored to the specifics of equine locomotion, are the key steps in eliminating abnormal joint stresses in equine athletes. In the absence of excessive forces acting on joints during locomotion, the mechanosensitive cells within the joint tissues are most likely to function in a manner that promotes maintenance of healthy joint homeostasis and regeneration, which would also aid in biologic therapy applications."